Modify Therapy/Monitor Closely. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. trientine, iron sucrose. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Modify Therapy/Monitor Closely. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator J Lab Clin Med; 111(5):566-70. Use Caution/Monitor. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Copyright 2021 GlobalRPH - Web Development by. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. The recipient will receive more details and instructions to access this offer. . iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Med J Aust; 193(9):525-32. (3) Known hypersensitivity to Venofer. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Applies only to oral form of both agents. Iron Product. Burns DL, Mascioli EA, Bistrian BR. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Applies only to oral form of both agents. Test Dose: Not required. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Applies only to oral form of both agents. 1982;13(4):309-21. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Do not double the dose to catch up. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Anemia; 2015: 763576. restrictions. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Dosage form: injection, solution Applies only to oral form of both agents. Venofer must only be administered intravenously either by slow injection or by infusion. Properly discard this product when it is expired or no longer needed. Applies only to oral form of both agents. Minor/Significance Unknown. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Crown Rump Length and Nuchal Translucency. Each costs about $0.46 to $0.55 per mg of iron. Venofer has not been studied in patients younger than 2 years old. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Modify Therapy/Monitor Closely. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Recommended dosing and infusion rates for PI. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Minor/Significance Unknown. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. . Maximum recommended single dose: 300 mg (See Prescriber's Orders). Official Journal of the International Society of Nephrology. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Either decreases levels of the other by inhibition of GI absorption. Dose. Applies only to oral form of both agents. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Schweiz Med Wochenschr; 100(7):301-3. The elemental iron product used is Iron sucrose 20 mg/mL. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Nutr Clin Pract. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Adding plans allows you to compare formulary status to other drugs in the same class. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. 2015: 763576. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). 2.1 . Avoid or Use Alternate Drug. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Contraindicated. Use Caution/Monitor. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Baloxavir may bind to polyvalent cations resulting in decreased absorption. World J Gastroenterol; 16(22): 27202725. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Steps on how to print your input & results: 1. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Minor/Significance Unknown. This calculator will help pinpoint potential causes of anemia based on Use Caution/Monitor. Applies only to oral form of both agents. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. commonly, these are "preferred" (on formulary) brand drugs. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. There is in depth information below the form on the method used and on the result provided. Applies only to oral form of both agents. Applies only to oral form of both agents. Many patients with kidney disease cannot get enough iron from food and require injections. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. By using this form you agree with the storage and handling of your data by this website. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. Applies only to oral form of both agents. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Separate by at least 4 hours. Last updated on Jun 1, 2022. Where: Medicine concentration Amount of active substance per a given volume of your drug. Suggested regime: Prescribing instructions Prescribing a single/first dose: 1) Ganzoni AM. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Use Caution/Monitor. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Separate dosing of tetracyclines from these products. Minor (1)iron sucrose, benazepril. Minor/Significance Unknown. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Use Caution/Monitor. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] The original formula employs the weight in kg but users can input it in lbs and it gets transformed. This site complies with the HONcode standard for trust- worthy health information: verify here. Minor/Significance Unknown. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Compare formulary status to other drugs in the same class. This site complies with the HONcode standard for trust- worthy health information: verify here. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Intravenous iron sucrose: establishing a safe dose. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Applies only to oral form of both agents. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Minor/Significance Unknown. Applies only to oral form of both agents. Observed Hb = the patients current hemoglobin in g/dl. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Separate dosing of tetracyclines from these products. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Venofer treatment may be repeated if necessary. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Ferric gluconate: 12.5 mg/mL. Applies only to oral form of both agents. Your doctor will do laboratory tests to monitor your response. Use Caution/Monitor. commonly, these are generic drugs. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Use Caution/Monitor. Controlled studies in pregnant women show no evidence of fetal risk. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. For additional Safety Information, please see Full Prescribing Information. Patients measured hemoglobin can be input in g/dL or mmol/L. Nutrition. Use Caution/Monitor. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Applies only to oral form of both agents. Anemia. Avoid or Use Alternate Drug. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Applies only to oral form of both agents.
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